Trailing 5-7 7-6 4-3 to Australia’s Daria Saville, Raducanu called an end to the match — which at three hours and 36 minutes was already the longest on the WTA Tour this season — soon after receiving treatment during a timeout.
Tuesday’s retirement means the 19-year-old has won just three of her eight matches since her stunning 2021 US Open win.
World No. 12 Raducanu, the No. 1 seed in Guadalajara, had a chance to serve for the match at 5-3 in the second set, but Saville — ranked 610th in the world — broke back and went on to force a tie break, which she won 7-4.
It was Saville’s first WTA main draw win since the 2021 Australian Open, the WTA said.
Saville also appeared to be struggling with an injury in the second set, but fought back to earn one of the biggest wins of her career.